Immunity, Cancer Prevention, Longevity, & Cardiovascular Support Factor One: Bio-Immunizer
	Provides anti-oxidants known to decrease free radical activity in the body. Scientists acknowledge it is these free radicals that damage DNA which is the primary cause of the aging process. Also contains protective nutrients to maintain vitality and sound cardiac condition.
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Research Report

Holistic Recommendations     Validation of Ingredients      References

REASONS TO CONSIDER (OVERVIEW)

• Individuals who wish to maintain good skin condition and a youthful appearance.
• Individuals exhibiting a family history of cardiovascular disease (CVD).
• Athletes engaged in aerobic sports such as runners, swimmers, cyclists, dancers and tennis players.
• Individuals who are 20% or more over ideal body weight.
• Individuals who consume fast foods (high in sugar, saturated fats and white flour) and luncheon meats (high in nitrite and nitrate preservatives).
• Heavy smokers and alcohol drinkers.
• Diabetics (Type II adult onset) and individuals with a family history of cancer.

       DOSAGE & DIRECTIONS

• Take two tablets daily with food on a consistent basis.
• There are no contraindications with this product when taken in the recommended dosage.

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Holistic Recommendations

Cartoonist Gary Trudeau hit the nail on the head when his main character, Michael Doonesbury, exclaimed "It's frightening to wake up one morning and discover that you've become your parents!"

It is clear that most Americans associate aging with disease and chronic ailments. Indeed, a comprehensive study by the Robert Wood Johnson Foundation determined that 99-million of us have chronic ailments such as heart disease, cancer, arthritis, diabetes, and high blood pressure which cost $470-billion a year in direct health costs.₉₅

However, this landmark study dispelled the commonly held belief that such chronic ailments are restricted to the elderly. The researchers discovered that only 26 percent of Americans with the above chronic conditions were 65 or older. The reason is simply:  

 

Aging is not a disease, it is a process intrinsic to every living organism. As we mature, it is junk food, tobacco, obesity, stress, alcohol abuse, and lack of exercise - not our genetic clock - that wears down our body and diminishes our immunity against disease. Immune system deficiency caused by toxins in the body causes individuals to age rapidly.

Over 1,400,000 of us will die this year from either heart disease, cancer, or strokes states the Centers for Disease Control and Prevention and all three are man-made, lifestyle-based, degenerative diseases that can be readily prevented with proper nutrients and behavioral modifications.

The human body is designed and programmed for rejuvenation at any age. The aliments of aging are determined by how we choose or don't choose to live our lives. As science continues to uncover the aging process, more and more findings link both deterioration and rejuvenation to the immune system.

It is now clear that the key to good health and a youthful body is a strong Immune System.

On September 13, 1993, a study of nearly 30,000 residents of north-central China was concluded by American and Chinese scientists. "The study is the first randomized trial to show a significant reduction in cancer in a population that has been supplemented with antioxidant vitamins and minerals," reported William Blot of the U.S. National Cancer Institute, who lead the study.

During 1994, biologists Rajindar Sohal and William Orr found the first direct evidence that antioxidants utilized against free radicals could extend life as well as improve its quality.₉₆

Based upon research and clinical studies conducted during 1997, the one sure anti-aging remedy that works is reducing food intake by 20 to 40 percent. One study conducted on rats determined that caloric restriction can have significant anti-aging effects even when started at age 45.₉₇

Two other studies conducted on monkeys, in an attempt to bring the results closer to what may occur in humans, also supported the theory that a reduction in intake of food may lead to a longer life._98,99

Unfortunately, this creates a Catch 22 nutritional situation. On one hand, mature adults require less calories to avoid obesity due to a reduction in basal metabolism.₁₀₀ Yet, if we maintain a low caloric intake it is next to impossible to get enough of the required nutrients our system requires - thanks to the poor quality of foodstuffs fostered upon us by agri-business and the junk food merchants!

In fact, a large percentage of older adults in this country are seriously malnourished.₁₀₁ The skin problems that are common in the elderly are nearly identical to the skin problems found in malnourished people in third world countries.₁₀₂

This makes a rational supplementation program mandatory for the health of the mature adult.₁₀₃

According to the Alliance of Aging Research, there are two ways in which the human system deteriorates and degenerates: Abuse, misuse or lack of use of our bodies and Immune Deficiency. Both are within our control and may be corrected through (1) proper diet including nutritional supplementation; (2) exercise; and (3) attitude.

Recommendations for enhancing Natural Immunity, Cardiovascular Conditioning and Body Rejuvenation.

1) Diet. Eat foods as close to their natural state as possible. There are over 2,800 FDA-approved additives with another 10,000 additives being "incidental" to the agriculture and food processing industry.₁₀₄

2) Eat a wide variety of foods. Individuals who eat a varied diet have a better nutrient intake than those whose diet remains staid.₁₀₅

3) Balance the diet. The diet should be balanced with the correct ratio of protein to fats to carbohydrates. Daily calories should be comprised of about 20% protein, 20% fat, and 60% carbohydrate, preferably complex carbohydrate.

4) Eat fish on a consistent basis. Individuals who eat at least two ounces of per week cut their heart disease risk in half.₁₀₆

5) Increase fiber consumption. Fiber is nature's broom which cleans out the intestines and keeps toxic substances from being absorbed. Fiber is found only in plant food; so maximize intake of fresh vegetables, fruit, legumes and whole grains.

6) Drink 6 to 8 glasses of water daily. Studies show an increase in water intake can actually reduce fat deposits. Water also helps to prevent sagging skin because cell are buoyed by water, which plumps the skin and leaves it clear, healthy and resilient.₁₀₇

7) Take a quality antioxidant supplement daily as they block the chemical reactions that generate free radicals while helping to destroy already formed ones.₁₀₈ They also help provide the added nutrients the average diet is lacking.

8) Exercise. The body evolved, and is designed, to be active rather than sedentary. Scientist have shown that diseases may be caused by the disuse of the body.₁₀₉   Regular exercise lowers blood pressure, fats in the blood and pulse rate while improving blood glucose, alertness, self-image, absorption of nutrients, and life span.₁₁₀
Aerobic exercise - jogging, walking, dancing, tennis, bike riding, swimming - can bring about a large increase in the muscles' oxidative capacity and is a key to good health.₁₁₁

9) Maintain ideal body fat composition as body weight, per se, has no bearing on health.₁₁₂ Ideal body fat percentage for men 50 years and over should fall between 20% and 25%. For women 50 years and over, body fat should fall between 27% and 31%.

10) Attitude. The mind is a potent determinant of the quality and quantity of a life. Social networking, and the extent of an individuals friends and relationships, is a major predictor of life span.₁₁₃

Attitude will influence whether exercise will be enjoyable or grueling and will determine if you are amenable to making diet and behavioral modifications.

11) Practice relaxation techniques. Internalized stress can precipitate heart attacks as well as depress the immune system.₁₁₄ In a study of over 2,000 individuals, depression doubled the risk for cancer.₁₁₅ (Consult Factor Six: Sommaserene Research Report for additional information on relieving stress)

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FACTOR ONE FORMULATION
Two Tablets Equal:

Validation of Ingredients

VITAMIN A (as pro-vitamin Beta Carotene) is effective at stimulating the immune system to protect the body and may aid in the prevention of certain cancers by acting as an antioxidant to maintain healthy cell membranes.₁

VITAMIN A (as Palmitate) is also included since this form of the vitamin can be absorbed in the absence of dietary fat and, second, many diabetics and hypo-thyroid individuals cannot convert beta carotene to vitamin A in their bodies.₂

A 19 year study of 2,000 healthy men showed there was a 700% increased incidence of lung cancer for the group with the lowest consumption of carotene-containing foods as compared with the highest carotene consumption group. Further, there was an 800% increase when only men who had smoked more than 30 years were evaluated.₃

An examination of 763 lung cancer patients in New Jersey revealed low carotene levels increased cancer risks by 130% above those with high carotene levels.₄

NOTATION: A controversial study published in the April 14, 1994 issue of the New England Journal of Medicine found that high doses of beta carotene actually raised the risk of lung cancer by 18 percent. The participants in this 10 year study received 20 mg of beta carotene a day (66,000 I.U.) which, in some cases, turned their skin yellow. This study - generally regarded to be flawed - illustrates that too much of anything can frequently do more harm than good!

Of 191 Italian women studied, those who averaged less than 3,300 IU of beta-carotene daily had eight times the risk of developing cervical cancer when compared to healthy controls.₅

Researchers looking at all stomach cancer victims in a four county region of Pennsylvania found that low intake of Vitamin A doubled the risk for stomach cancer.₆

An Oxford physician estimates that optimal intake of beta-carotene alone could reduce cancer incidence by one-third.₇ A large percentage of people in America and Canada have serum levels of A that are indicative of a marginal deficiency.₈

THIAMINE (VITAMIN B-1) is required for the normal functioning of all body cells, especially nerves. This vitamin enhances circulation, blood formation and carbohydrate metabolism. Anything that increases the demand for the conversion of carbohydrate to energy - such as exercise, alcohol and especially sugary foods - will increase the likelihood of deficiency symptoms in a diet low in thiamine.₉

RIBOFLAVIN (VITAMIN B-2) is necessary for red blood cell formation, antibody production, cell respiration and the normal release of energy from carbohydrate, protein, and fat in food. When used with vitamin A, it maintains and improves the mucous membranes in the digestive tract.₁₀

While most healthy people excrete measurable amounts of riboflavin daily, 80% of all cancer patients, regardless of the site of the tumor, excrete virtually no riboflavin in their urine.₁₁

This B vitamin is easily destroyed by cooking, antibiotics and alcohol.₁₂

NIACIN as NIACINAMIDE (Niacinamide does not produce skin flushing, headaches or tingling regardless of the dose). Niacin decreases blood cholesterol, LDL-cholesterol, triglyceride levels and reduces the risk for developing cardiovascular disease in people with elevated blood fat levels.₁₃

Two hundred scientists from around the world have discovered that niacin plays a major role in the prevention and treatment of cancer.₁₄

PYRIDOXINE (VITAMIN B-6) is required by the nervous system and is necessary for normal brain function and for the synthesis of RNA and DNA (nucleic acids). Pyridoxine has a role in cancer immunity and arteriosclerosis. It inhibits the formation of a toxic chemical called homocysteine, which attacks the heart muscle and allows the deposition of cholesterol around the heart muscle.₁₅

Pyridoxine has been shown to inhibit cancer cell growth in culture dishes and even lends greater cancer resistance to mice that are given injections of skin cancer cells.₁₆ Approximately 40% of Americans are low in their intake of pyridoxine.

FOLIC ACID (FOLACIN) is a B vitamin that is involved in directing new cell growth in the body. A folic acid deficiency causes damage to cells that resembles the initial stage of cancer. Women who take folic acid supplements show less precancerous cervical tissue as compared to women who consume a diet low in the vitamin. Folic acid might prevent the transformation of abnormal cells to cancer cells and might return damaged tissue to a healthy condition.₁₇

A recent study has found that folic acid and vitamin B6 significantly lowered the risk of coronary heart disease and, in fact, folic acid deficiencies could trigger 30 to 40 percent of the heart attacks and strokes suffered by Americans each year.₁₈

Folic acid is one of the most common vitamin deficiencies. Surveys show that the folic acid content of the American diet is half the recommended dietary intake. Many major categories of drugs, including oral contraceptives, aspirin, and anticonvulsants can produce a folic acid deficiency.₁₉

NOTE: Folic acid can mask a B12 deficiency but is in-effective against the nerve damage a B12 deficiency can cause. For this reason, the amount of folic acid in nutritional supplements is limited by law to 400 mcg for adults and 800 mcg for pregnant women.

VITAMIN C (CALCIUM ASCORBATE) in the body inhibits cancer and the absence of this important nutrient increases cancer risk. Vitamin C stimulates the immune system to attack abnormal cells and prevent destruction of the DNA.₂₀ It stimulates the production of interferon, a potent anti-cancer agent in the body₂₁ and blocks the formation of carcinogenic nitrosamines in the stomach.₂₂

Individuals who are well nourished with vitamin C are less likely to get cancer of the esophagus, stomach, bladder and other areas of the body.₂₃ In a study of over 6,300 Swiss adults, low levels of vitamin C increased the risk for all types of cancer.₂₄

NOTE: Smokers bind up large amounts of vitamin C through tobacco use - as much as 500 mgs per pack of cigarettes. Of 139 patients with lung cancer, most had blood levels of vitamin C indicating a deficiency, with some people testing in the scurvy range.₂₅

Adequate intake and maintenance of high blood levels of vitamin C might help regulate blood sugar since low vitamin C levels in white blood cells are found in diabetics.₂₆

VITAMIN D (AS CALCIFEROL) is necessary for normal nerve transmission and muscle contraction, including the heartbeat and might alter the growth of several different types of cancer, including colon cancer and non-Hodgkin's lymphoma.₂₇

Vitamin D might function in the normal production or secretion of the hormone insulin from the pancreas. In this capacity, the vitamin might aid in the regulation of normal blood sugar.₂₈

NOTE: Those who spend a great deal of time in the sun during the entire year are not particularly prone to develop melanomas, according to the 1985 report "Sunlight and skin cancer" published in the New England Journal of Medicine. Individuals prone to skin cancer are those who normally live in temperate climates, spend most of their time indoors, and then expose themselves to intense sunlight by spending occasional weekends on the beach or winter vacations in the tropics. In short, consistency and/or moderation is the key to enjoying the "sunshine vitamin" without risking cancer.

VITAMIN E (d-ALPHA TOCOPHEROL) is an antioxidant that improves circulation, repairs tissue, promotes normal clotting and healing, improves athletic performance and protects fats and vitamin A in the body from destruction by oxygen fragments or free radicals. In a 14-year study of over 5,000 British women, low vitamin E levels in the blood increased the risk for breast cancer by 500%.₂₉

Vitamin E and selenium work together in a potent anti-cancer enzyme system called glutahione peroxidase (GSH), a critical tool for the body to ward off cancer.₃₀ The levels of GSH in the body depend greatly on the levels of vitamin E and selenium in the diet.₃₁
Vitamin E may aid in the prevention of premature heart disease by inhibiting the clumping of blood cell fragments called platelets that are associated with atherosclerosis.₃₂

Reports show that vitamin E might reduce blood sugar levels in some diabetics. In one study, blood sugar levels decreased 20% when patients increased vitamin E intake to 2,000 IU's a day.₃₃

CHROMIUM (PICOLINATE) is a component of glucose tolerance factor (GTF), a substance that works with insulin to facilitate the uptake of blood sugar and is needed for energy. This essential mineral maintains stable blood sugar levels through proper insulin utilization in both the diabetic and the hypoglycemic.₃₄

Low plasma chromium levels are an indication of coronary artery disease. As many as 90% of all American diets are low in chromium due to a lack of this mineral in our soil and by a diet high in white sugar, flour and junk food.₃₅

SELENIUM (Organic) is a vital antioxidant which protects the immune system by preventing the formation of free radicals. Selenium has been shown to improve the efficiency with which DNA can repair itself after being exposed to damaging substances.₃₆

Professors from Cornell University₃₇ and the University of California₃₈ have stated that at least 55 different studies show the anti-cancer effect of selenium.

In a study, blood samples were taken from 10,000 Americans and then frozen. Over the next five years, the individuals in this study who developed cancer had their blood samples unfrozen and checked for selenium levels. Cancer victims were found to have had the lowest levels of selenium in their blood at the start of the study.₃₉

People in Finland who had plasma selenium levels that ranked in the lowest third had three times the risk for cancer₄₀ indicating a nearly straight-line relationship between selenium levels and cancer incidence.

The average American diet contains about 33 mcg of selenium daily. For healthy, nonstressed adults, 70 to 80 mcg daily would be necessary just to replace the selenium that is excreted in stools and urine.₄₁

NOTE: Organic selenium (yeast derived) is better tolerated, better absorbed, and less likely to cause toxicity than inorganic selenium, such as sodium selenite. Most yeast derived selenium is bound to the amino acid methionine which improves bioavailability and circulating levels of selenium in the blood.₄₂ A person cannot get yeast infection from yeast-derived selenium, even those who believe they are very intolerant of it!

ZINC (PICOLINATE) is required for protein synthesis and collagen formation. Even mild deficiencies of zinc result in poor wound healing.₄₃

Zinc has a beneficial effect on the immune system and the body's natural defense against colds, infection, and disease as it inhibits the growth of disease-causing bacteria.₄₄

Zinc serum levels are markedly lower in patients with cancer of the esophagus, lungs, and prostate gland.45 Rats that are given zinc supplements and then exposed to carcinogens have fewer tumors.₄₆

Zinc deficiency is not uncommon in athletes, vegetarians, elderly populations, and hospital patients.₄₇

ASTRAGALUS MEMBRANACEUS ROOT (FROM EXTRACT) generally increases immunity by increasing the numbers and activity of roving white blood cells.₄₈ and is an extensively utilized traditional herb in Chinese medicine.

In a study reported in the Chinese Medical Journal, astragalus root was found to increase the life span of human cells in culture.₄₉

Studies conducted at the University of Texas Medical Center compared damaged immune system cells from cancer patients to healthy cells. Astragalus extracts were able to completely restore the function of cancer patients' immune cells,₅₀, ₅₁ sometimes surpassing the activity of those from healthy human subjects.

Astragalus also lowers blood pressure, increases endurance and protects the liver from poisons.₅₂

GINSENG (KOREAN PANAX FROM EXTRACT) is a root herb that has a 5,000-year old track record and concrete scientific data to prove its value. Scientists at Japan's Kanazawa Medical University recently discovered that saponins from Panax ginseng actually caused cultured liver cancer cells to convert to normal functioning liver cells, a process they describe as "decarcinogenesis".₅₃

Ginseng has been shown to stimulate the immune system,₅₄ increase stamina and vigor,₅₅ improve coordination and reflexes,₅₆ improve oxygen capacity of the lungs,₅₇ improve blood flow,₅₈ and lower total cholesterol - especially the low-density (LDL) cholesterol - thought to increase heart disease risk.₅₉

MILK THISTLE (SILYMARIN FROM EXTRACT) is a flavonoid seed extract used as a liver remedy for at least two thousand years and as a protective compound against liver-damaging agents. It demonstrates good antioxidant properties, both in vivo and in vitro.₆₀

Silymarin helps the regeneration of liver cells damaged by toxins and disease such as hepatitis.₆₁,₆₂ In numerous clinical studies, this powerful phytochemical has been shown to have positive effects in treating several types of liver disease, including cirrhosis, chronic hepatitis, fatty infiltration of the liver, and alcohol induced liver disease.₆₃, ₆₄, ₆₅, ₆₆

ANGELICA SINESIS FROM EXTRACT, commonly referred to as Dong Quai, has demonstrated immuno-stimulating activities. These include the induction of interferon production, stimulation of immune cell proliferation and anti-tumor activity.₆₇

Angelica also possesses significant blood pressure lowering action₆₈ and relieves vasospasms.₆₉

Other cardiovascular effects noted for angelica include antiarrhythmic actions, inhibition of platelet aggregation, and increase in blood flow to the heart, brain, and extremities.₇₀, ₇₁

ECHINACEA ANGUSTIFOLIA FROM EXTRACT has been shown to possess significant anti-tumor activity in experiments with rats.₇₂ Echinacin, the active constituent of Echinacea, exhibits interferon-like activity and protects cells against virus related diseases.₇₃

German research has demonstrated another immuno-stimulating property of this plant - its ability to stimulate T-cell activity. This cell is an important mediator in the body's immune system.₇₄

Further, Echinacea extracts stimulate stem cells in bone marrow and lymphatic tissue where immune system cells are produced, and increase the number and activity of these immunocompetent cells in the blood and lymphatic circulation.₇₅

Studies suggest that Echinacea significantly stimulates the body's own blood cleansing system.₇₆

CHAMOMILE (ANTHEMIS NOBILIS) FROM EXTRACT is a time-tested plant remedy with calming and anti-inflammatory actions.₇₇

Chamomile has been used against benign as well as malignant tumors and carcinomas of the liver, stomach, mouth, skin and brain, internally as well as externally.₇₈

A principal flavonoid found in chamomile is apigenin, a nontoxic and non-mutagenic flavonoid with significant potential as being a cancer preventive agent.₇₉

LICORICE (GLYCYRRHIZA GLABRA) FROM EXTRACT contains a triterpene saponin called glycyrrhizin which is about fifty times sweeter than sugar and exhibits a powerful cortisone-like effect. Some European researchers have concluded that this natural product may be preferred to cortisone because it is safer, especially when prolonged treatment is required.₈₀

Russian researchers have found that licorice root inhibits the growth of certain tumors (sarcoma-45 and Ehrlich ascites cells).₈₁

Another study found that the herb actually stimulates the production of interferon, a critical chemical in the immune system that could be the key to preventing and treating many immune-response deficiency diseases in the future.₈₂

GRAPE SEED EXTRACT (95% active polyphenols) is the highest quality procyanidolic oligomers (PCO's) obtainable from grape seed extract. The activity of these PCO's is approximately fifty times greater than that of vitamins C or E, in terms of antioxidant action.₈₃ Numerous studies now show that the level of antioxidants may be a more significant factor than cholesterol levels in determining the risk of developing heart disease.

A 7-year study, begun in 1985, demonstrated that when flavonoid intake of PCO's was high, the risk of having a heart attack was low. Conversely, if flavonoid intake was low, the risk of heart attack was high.₈₄

PCO extracts include an ability to increase intracellular vitamin C levels, decrease capillary permeability and fragility (including diabetic retinopathy), scavenge oxidants and free radicals, and inhibit destruction of collagen.₈₅,₈₆,₈₇ (One of the major factors in male impotence is damaged capillaries in the penis).

The average daily intake of total flavonoids per person in the U. S. is estimated to be 25 milligrams. An intake greater than 30 mg significantly reduces the risk of cardiovascular mortality.₈₈

NOTE: It has been demonstrated that grape seed extract may be more potent and effective than pine bark extract, sold in the U.S. under the trade name Pycnogenol.₈₉

GARLIC (from 1000 mg. fresh garlic with chlorophyll) has been extensively studied for its beneficial effects on the heart. Studies have shown that garlic can lower cholesterol and triglycerides in the blood. It's so effective, it can prevent human cholesterol levels from rising even when garlic is consumed with the equivalent of a full stick of butter.₉₀

A recent study confirmed that garlic was found to produce significant reductions in serum cholesterol levels, while raising the level of HDL which protect against artery-hardening plaque.₉₁

Consumption of garlic (allium) was investigated in 1,695 humans, 564 of whom had stomach cancer. Cancer incidence dropped dramatically with increased allium consumption.₉₂

The anti-cancer effects of garlic were confirmed recently by the Journal of the National Cancer Institute.₉₃ Chlorophyll may also prevent cancer.₉₄

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