Herbal Antibiotic & Anti-Viral Agent Factor Twelve: Opti-cillin
	This formulation contains herbal extracts shown to provide anti-bacterial, anti-viral, and anti-fungal properties which support the immune systems ability  to ward off  infections and infectious diseases.
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Research Report

Validation of Ingredients     Holistic Recommendations      References

DOSAGE & DIRECTIONS

Recommended dosage is 3 capsules twice daily for 10 days for maximum benefit. Do not discontinue before vial has been depleted. May be taken with or without food.

 

 

CONTRAINDICATIONS & PRECAUTIONS

This formulation is safe for both children and the elderly. There is no known toxicity or contraindications with this product when taken in the recommended dosage. However, do not take this product with the prescription anticoagulant drug Cumadin (Warfarin). Also, do not take during pregnancy. As with all dietary supplements, do not take at the same time as medications.

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Holistic Recommendations

Common cold, Influenza, Bronchitis & Pneumonia.

 

All of these conditions are infections of the upper respiratory tract caused by viruses which are impervious to synthetic antibiotics. The patient's immune system plays a large role in determining whether the body will fight off such infections.

 

Both the common cold and the "flu" are highly contagious because they can be spread easily by coughing and sneezing. Although both a cold or flu is rarely fatal by themselves, they do make the patient more susceptible to bronchitis, pneumonia, and sinus trouble.

 

The growing population of individuals with chronic lung diseases primarily due to smoking and immunosuppressive drugs has contributed to further increases of chronic bronchitis and serious pneumonias, which have very high mortality rates.₅₃

 

It is most important therefore to boost the immune system to prevent the cold or flu from developing into something more significant. It will also reduce the severity and duration of the symptoms.

 

Exposure to a disease-causing microorganism does not always cause infections in the body and result in symptoms. The immune system plays a major role in determining whether the body will fight off infection.

 

Upon the very first sign of cold or flu symptoms (watery nasal discharge, sneezing, coughing, watery red eyes, general malaise) - or if individuals in close contact exhibit such signs - the patient should begin the recommended daily dosage of Factor Twelve:Opti-cillin and continue for the full ten day period until the entire vial has been depleted. This will assist the immune system in destroying such viruses and clear the infection before the on-set of disease.

 

Studies have linked malnutrition to viruses. Scientists have recently found the first direct evidence that viruses can mutate and become deadly because of nutritional deficiencies in the hosts they infect.₅₄ If the nutritional status of the infected person proves to affect other disease-causing viruses it may turn out to be a factor in the evolution of more deadly forms of influenza, hepatitis and meningitis.₅₅

 

It is recommended that Factor One: Bio-Immunizer be incorporated into the patient's nutrition program during viral exposure. Patients with a compromised or depressed immune system subject to chronic colds and upper respiratory infections should consider taking Factor One: Bio-Immunizer as a preventative on a consistent basis.

 

If the patient is experiencing an advanced stage of a cold or flu attack, Factor Nine: Liverzyne may be incorporated into the natural antibiotic regime noting precautions.

 

Bladder and Urinary Tract Infection

Bladder and urinary infections are usually caused by E. coli bacteria resulting in cystitis, an inflammation of the bladder.

 

Twenty-one percent of women have urinary infections at least once a year which may be uncomfortable or extremely painful and thirty-seven percent of women with no history of urinary infection will have one within 10 years.₅₆

 

Symptoms are characterized by an urgent desire to empty the bladder. Urination is typically frequent and painful, such as a burning sensation and the urine may appear cloudy.

 

Recent clinical data suggests that ampicillin, trimethoprim, and trimetho-sulfamethoxazole, now used as first line treatment of acute cystitis, may not be acceptable choices for therapy much longer.₅₇

 

It is imperative that patients experiencing the first signs of a urinary tract infection begin dosing with Factor Twelve: Opti-cillin and immediately incorporate Factor Eleven: CranPlex into their daily supplement regime.

 

Ear Infections, There are three types of earache:

 

1) External otitis (swimmer's ear) is an infection of the external ear canal with itching, discharge or burning pain;

 

2) Acute otitis media (also known as bacterial otitis media) is an infection of the middle ear and usually preceded by an upper respiratory infection or allergy; and

 

3) Chronic otitis media (also known as serious otitis media) refers to a constant swelling of the middle ear.

 

A number of studies have confirmed that there are no significant differences in the clinical course of acute otitis media when conventional treatments are compared with placebos except that children not receiving antibiotics had fewer recurrences than those who did receive antibiotics.₅₈

 

In fact, subsequent studies revealed that children with chronic otitis media who took amoxicillin experienced 2 to 6 times more recurrent ear infections as compared to those on placebo.₅₉

 

Upon the first signs of ear infection, the patient should begin the recommended daily dosage of Factor Twelve: Opti-cillin and continue for the full ten day cycle until the entire vial has been depleted.

 

For prevention of reoccurring ear infections, the vast majority of patients with recurrent ear infections improved after removing food allergens from their diets.₆₀

 

Fungal Skin Infections

 

Candida albicans is the most common form of yeast-like fungus. When it infects the oral cavity, it is called thrush. When it infects the vagina, it results in vaginitis. Athlete's foot, ringworm and jock itch also develop as a result of a fungal infection. Moist red patches anywhere on the body often indicate an infection by fungal or, in some cases, staph bacteria.

 

A depressed immune function is a leading cause of most fungal infections. At the on-set of a fungal infection begin dosing with Factor Twelve: Opti-cillin for the full 10 day cycle and consider using Factor One: Bio-Immunizer as a preventative. (Women should consider Factor Ten: Femtrac)

 

Food Poisoning and 'Traveler's Diarrhea'

 

Food poisoning occurs when a person consumes food containing harmful bacteria. Each year more than two million Americans report illnesses that have been traced to foods that were eaten. And this is just the tip of the iceberg! Up to 275 million of the cases of diarrhea reported annually are directly related to foods eaten.₆₁

 

Cryptosporidium bacterium in the Milwaukee water supply sickened an estimated 403,000 and sent about 4,400 to the hospital.₆₂ Another microbe, known as cyclospora, is suspected to have made more than 1,000 people sick in 11 states.₆₃ Not a week goes by that the media does not report an outbreak of food poisoning somewhere in the United States, usually caused by salmonella, Staphylococcus aureus, or E. coli bacterium. In fact, each year hundreds of thou-sands of Americans get sick with salmonella poisoning caused by a strain that is resistant to five antibiotics!₆₄

 

Symptoms of food poisoning include nausea, vomiting, and cramps. If the patient suspects food poisoning, he should begin the recommended dosage of Factor Twelve: Opti-cillin and continue for the full cycle until the vial is depleted.

 

For those planning to travel to a foreign country or an area of poor water quality or sanitation, the prophylactic use of Factor Twelve: Opti-cillin 5 days prior to, during, and 5 days following visiting, may be useful.

 

Herpes simplex HSV-1 and HSV-2

 

Herpes simplex is a recurrent viral infection of the skin or mucous membranes. After entering the body, the virus never leaves. it can only be kept under control so it will not break out in painful fluid-filled blisters that form around the mouth and/or genitals. Cold sores are caused by herpes simplex virus type 1 (HSV-1) while genital herpes are caused by the type 2 virus (HSV-2).

 

After initial infection - via direct contact with contaminated saliva, skin discharge, or sexual fluids - the sores appear two to seven days after exposure.

 

Recurrent eruptions are common and usually follow minor infections, trauma, emotional stress, or poor dietary habits.₆₅

 

Current estimates indicate that 20 to 40 percent of the U.S. population have recurrent herpes infections.₆₆

 

Not everyone exposed to HSV develops the disease. Persistent infections are seen in immunosuppressed individuals. The cell-mediated immune system is perhaps the major factor in determining the outcome of herpes exposure.

 

Immediately upon the onset of cold sores and/or genital blisters, the patient should begin Factor Twelve: Opti-cillin in the recommended dosage until vial has been depleted.

 

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FACTOR TWELVE FORMULATION
Two Capsules Equal:

Validation of Ingredients

CAMELLIA SINENSIS (GREEN TEA) EXTRACT (50% polyphenol content) contains potent antioxidant compounds that have demonstrated greater antioxidant protection than vitamins C and E in experimental studies as well as exhibit anti-allergy activity._1,2 Green tea extract is also rich in Theophylline, a compound used as a prescription drug in the treatment of asthma.₃

 

The polyphenols in camellia sinensis have also been shown to stimulate the production of several immune system cells, and have antibacterial properties - even against the bacteria that cause dental plaque._4,5,6 In fact, the polyphenols are believed to be responsible for most of green tea's role in promoting good health.₇

 

Green tea polyphenols inhibit cancer by blocking the activation of carcinogens, and detoxifying or trapping cancer-causing compounds such as nitrosamines, suppressing the activation of carcinogens, and detoxifying or trapping cancer-causing agents. The forms of cancer that appear to be best prevented are cancers of the gastrointestinal tract, the stomach, small intestine, pancreas, colon, lung cancer, and estrogen-related cancers including most breast cancers_8,9

 

Camellia sinensis guards against cardiovascular disease by lowering total cholesterol levels while improving the cholesterol profile of LDL to HDL cholesterol and lowering blood pressure._10,11

 

BERBERIS ALKALOID EXTRACT containing the major alkaloid, berberine, has been extensively studied in clinical settings. Berberine has shown antibiotic activity against bacteria, protozoa, and fungi, including Staphylococcus species, Streptomyces species, Corynebacterium diphtheria, E. coli, salmonella typhi, Diplococcus pneumoniae, Trichomonas vaginalis, N. meningitidis, and Candida albicans._12,13,14

 

Berberine has the ability to inhibit the adherence of streptococci to host cells. Simply stated, berberine interferes with infections due to streptococci not only by inhibiting streptococcal growth, but also by blocking these organisms to host cells.₁₅

 

Berberine has been found effective against diarrheas caused by E. coli (traveler's diarrhea), Shigella dysenteriae (shigellosis), Salmonella paratyphi (food poisoning), and Vibrio cholerae (cholera). Clinical studies have produced results with berberine comparable to those of standard antibiotics in most cases, and in several studies results were actually superior._16,17,18

 

ECHINACEA (ANGUSTIFOLIA) EXTRACT activates a part of the immune system known as the alternate complement pathway. As a result, the movement of white blood cells into areas of infection is enhanced; immune complexes solubilize; and bacteria, viruses and other microorganisms are destroyed._19,20

 

Echinacea elevates serum white blood cell counts when they are low, including T lymphocytes, or T cells.₂₁ These cells are a type of white blood cell responsible for "cell-mediated immunity" which refers to immune mechanisms not controlled or mediated by antibodies. This is extremely important in providing resistance to infection by mold-like bacteria, yeast, fungi, parasites, and viruses including those that cause hepatitis._22,23

 

Cell-mediated immunity is also critical in protecting against the development of cancer, autoimmune disorders such as rheumatoid arthritis, and allergies. Echinacea has been successfully utilized to treat all of these conditions.₂₄

 

Echinacea extract stimulates stem cells in bone marrow and lymphatic tissue where immune system cells are produced, and increase the number and activity of these cells in the blood and lymphatic circulation.₂₅

 

It has been stated that Echinacea is one of the most powerful and effective remedies against bacteria and viral infections.₂₆

 

PANAX GINSENG ROOT EXTRACT (standardized to 5% ginsenosides) exerts numerous pharmacological effects including antistress activity, improved endocrine system function, enhanced protein synthesis and cell reproduction; improved glucose control in diabetics; lowering of serum cholesterol; and protection of the liver from toxic substances._27,28,29,30

 

Ginseng possesses immunostimulating activity as evidenced by its ability to enhance antibody responses, cell-mediated immunity and the production of interferon.₃₁

 

Ginseng also has the ability to enhance the activity of the cells of the reticuloendothelial system. This system is composed of white blood cells known as macrophages, which filter the blood and lymph by engulfing and destroying bacteria, viruses, and other waste matter. Such macrophages are found in highest concentrations in the liver, spleen, and lymph nodes.₃₂

 

The liver contains specialized macrophages known as Kupffer cells. Ginseng stimulates and increases the activity of these cells which are responsible for removing toxins and debris from the circulation.₃₃ Ginseng has also been demonstrated to increase protein synthesis in the liver which is often reduced in the elderly.₃₄

 

Clinical studies have shown that ingestion of ginseng by individuals with mild immune deficiency (frequent colds) may reduce the risk of viral infection.₃₅

 

USNEA (USNEA BARBATA) contains usnic acid which acts as an antibiotic. Unlike other antibiotics which disrupt structural components of bacterial cells, usnea kills microbes by disrupting cellular metabolism. Also, unlike synthetic antibiotics which kill the natural flora in the vagina and gut, usnea does not destroy "friendly" bacteria and therefore does not adversely affect the body's natural ecology.₃₆

 

Usnea has been found to be especially effective for acute bacterial infections. Many individuals have also had great success using usnea for sinusitis, bronchitis, pneumonia, and colds when nothing else had worked.₃₇

 

OCIMUM BASILICUM exhibits in vitro antibacterial activity against Bacillus subtilis, E. coli, Pseudomonas auerginosa, and Staphylococcus aureus. Strong activity was also shown against Candida albicans.₃₈

 

Ocimum basilicum is also a galactagogue and stomachic. It is useful for stomach cramps, gastric catarrh, vomiting and intestinal catarrh which are symptoms usually associated with colds, flu, and similar virus ailments.₃₉

 

ROSMARINUS OFFICINALIS contains some of the most powerful candida killing substances available.₄₀ The active constituents of this herb include eucalyptol which exhibits antibacterial effects₄₁ and relaxes smooth muscles in the lungs.₄₂ Rosmarinic acid has significant antioxidant activity.₄₃

 

The stimulant action of rosemary helps promote liver function, the production of bile, and proper digestion. It also acts to improve circulation.₄₄

 

GARLIC EXTRACT (from 66 mg fresh garlic) were found to be effective antibiotic agents against many bacteria, including Staphylococcus aureus, Escherichia coli, salmonella enteritidis, Klebsiella pneumoniae, and mycobacteria._45,46,47 These studies compared the antimicrobial effects of garlic with those of commonly used antibiotics, including penicillin, streptomycin, chloramphenicol, erythromycin, and tetracyclines. These studies demonstrated garlic's efficacy in inhibiting the growth of some bacteria that had become resistant to one or more of the antibiotics.

 

Garlic possesses important immune-enhancing and anticancer properties. Human studies show that garlic inhibits the formation of nitrosamines which are powerful cancer-causing compounds formed during digestion.₄₈

 

Garlic has demonstrated significant antifungal activity against a wide range of fungi. Garlic is especially active against C. albicans, being more potent than Nystatin and six other reputed antifungal agents.₄₉

 

Garlic's antiviral effects have been well studied. In vitro, fresh garlic killed herpes simplex types 1 and 2, Para-influenza virus type 3, vesicular stomatitis virus, and human rhinovirus type 2. Fresh garlic extract was virucidal against all viruses tested but the virucidal activity of commercial products depended how they were prepared. Those products producing the highest level of allicin and other thio-sulfinates, such as found in Factor Twelve: Opti-cillin, had the best virucidal activity.₅₀

 

Based on clinical research, the dosage of a commercial garlic product should provide a daily dose of 4 mg of allicin.₅₁

 

CHOROPHYLLIN (pure) is "natures deodorant" and aids in cleansing of the bloodstream.₅₂ According to G. W. Rapp in the American Journal of Pharmacy, chorophyllin also possesses positive antibacterial action and reduces the hazard of bacterial contamination. It's main purpose in this formulation, however, is to off-set some of the more pungent herbal extracts utilized in Factor Twelve: Opti-cillin.

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References

1. Ho, C, et al, Prev Med, vol 21, pp 520-25, 1992

2. Murray, M, et al, Encyclopedia of Natural Medicine, Prima Publishing, Rocklin, CA, p 445, 1991

3. Ibid

4. Stoner, GD, et al, Journal of Cell Biochemistry, vol 22, pp 169-80, 1995

5. You, SQ, Chin J Stom, vol 28, no 4, pp 197-99, 1993

6. Hamilton-Miller, JM, Antimicrobia Ag Chemo, vol 39, no 11, pp 2375-77, 1996

7. Graham, HN, Preventative Medicine, vol 21, pp 334-59, 1992

8. Yang, CS, et al, Journal Nat Cancer Institute, vol 85, no 13, pp 1038-49, 1993

9. Komori, A, et al, Japan J Clinical Oncology, vol 23, no 3, pp 186-90, 1993

10. Sagesaka-Mitane, Y, et al, Chem. Pharm Bulletin, vol 38, no 3, pp 186-93, 1990

11. Stensvold, I, et al, Preventative Medicine, vol 21, pp 546-53, 1992

12. Hahn, EE, et al, Antibiotics, vol 3, pp 577-88, 1976

13. Amin, AH, et al, Can J Microbiol, vol 15, pp 1067-76, 1969

14. Kaneda, Y, et al, Am Trop Med Parasitol, vol 85, pp 417-25, 1991

15. Sun, D, et al, Antimicrob Agents Chemother, vol 32, pp 1370-74, 1988

16. Sack, RB, et al, Infect Immun, vol 35, pp 471-75, 1928

17. Khin-Maung, U, et al, British Medical Journal, vol 291, pp 1601-05, 1985

18. Rabbani, GH, et al, Journal of Infectious Diseases, vol 155, pp 979-84, 1987

19. Bauer, R, et al, Econ Med Plant Res, vol 5, pp 253-321, 1991

20. Mose, J, Med Welt, vol 34, pp 1463-67, 1983

21. Ibid

22. Djonlagie,H, et al, Gastroenterol, vol 1, pp 19-22, 1975

23. Foster, S, Echinacea-Nature's Immune Enhancer, Healing Arts Press, Rochester, VT, 1991

24. Ibid

25. McCaleb, R, Herb Research Foundation, Jan 19, 1991

26. Terra, M, Planetary Herbology, pp 190-91, 1988

27. Shibata, S, et al, Econ Med Plant Res, vol 1, pp 217-84, 1985

28. Liberti, LE, et al, Journal Pharm Science, vol 67, pp 1487-89, 1978

29. Bombardelli, E, Ginseng: Chemical, Pharmacological, and Clinical Profile,            Indena  S.p.A., Milan, Italy, 1989

30. Minmo, Y, et al, Chem Pharm Bulletin, vol 28, pp 2687-91, 1980

31. Gupta, S, et al, Clin Res, vol 28, p 504A, 1980

32. Ibid

33. Bombardelli, E, et al, Proceedings 3rd International Ginseng Symposium, pp 9-16, 1980

34. Oura, H, et al, Planta Medica, vol 28, pp 76-88, 1975

35. Scaglione, F, et al, "Immunomodulatory effects of Panax ginseng extracts", Drugs Exp Clin Res, vol 16, pp 537-42, 1990

36. Weiss, R, Herbal Medicine, Beaconsfield Publishers, Ltd, UK, p 49, 1988

37. Evans, WC, Trease and Evans' Pharmacognosy, 13th ed, London, Bailliere     Tindall, p 643, 1989

38. Arvigo, R, 'Herbal Alternatives to Antibiotics', Natural Pharmacy, vol 3, no 2,    Feb 1999

39. Lust, J, The Herb Book, Bantam Pub, 1974

40. Duke, JA, Handbook of Medicinal Herbs, CRC Press, Boca Raton, FL 1985

41. Huhtanen, C, Journal Food Protection, vol 43, pp 195-96, 1980

42. Aqel, MB, Journal Ethnophamacol, vol 33, pp 57-62, 1991

43. Leung, AY, et al, Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and Cosmetics, 2nd ed, John Wiley, NY, pp 446-48, 1996

44. Lust, J, The Herb Book, Bantam Pub, 1974

45. Adetumbi, MA, et al, 'Garlic - a natural antibiotic', Med Hypothesis, vol 12, pp 227-37, 1983

46. Hughes, BG, et al, Phytother Res, vol 5, pp 154-58, 1991

47. Elnima, EI et al, 'The anti-microbial activity of garlic', Pharmagie, vol 38, pp 747-48, 1983

48. Mei, X, et al, Acta Nutr Sin, vol 11, pp 144-45, 1989

49. Collins, EB, Journal Dairy Science, vol 63, pp 830-32, 1980

50. Weber, ND, et al, Planta Medica, vol 58, pp 417-23, 1992

51. Ibid

52. Balch, JF, Prescription for Nutritional Healing, p 39, 1990

 

Validation of Holistic Recommendations

 

53. Rubenstein, E, et al, Scientific American Medicine, Scientific Am., p 7, 1984

54. Beck, M, Journal of Nature Medicine, May 1, 1996

55. Ibid

56. Branch, WT, Office Practice of Medicine, W.B. Saunders, Phil, PA, pp 679-85, 1982

57. Blumer, JL, et al, Journal American Medical Assoc, Feb 24, 1999

58. vanBuchen, FL, et al, Lancet, vol ii, pp 883-87, 1981

59. Cantekin, EL, et al, Journal of the American Med Assoc, vol 266, no 23, pp 2309-17, 1991

60. Family Practice News, vol 21, no 5, p 14, 1991

61. Balch, JF, Prescription for Nutritional Healing, Avery Publishing Group, Garden   City Park, NY, p 180, 1990

62. Manning, a, USA Today Cover Story, June 17, 1994

63. New York Times, Health & Medicine Section, June 30, 1996

64. Associated Press Report, May 7, 1998

65. Rubenstein, E, et al, Scientific American Medicine, Scientific American, NY p 7, 1988

 

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