Herbal Based Natural Pain Control Factor Fourteen: Anodyne Plus
	A synergistic formulation of herbals and other nutrients shown to have pain relieving properties against neurological disorders, chronic back and joint pain, and migraine head ache.   Botanicals offer a broader range of possible therapeutic actions then  pharmaceutical drugs in combating chronic pain and have less side effects and  contraindications.   Factor Fourteen: Anodyne Plus has no known side effects.
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Research Report

Holistic Recommendations     Validation of Ingredients      References

REASONS TO CONSIDER (OVERVIEW)

• Adults with chronic back pain, lumbar strain, and coccyx pain.
• Individuals experiencing persistent muscle spasm.
  (Recommended in combination with Factor Six)
• Those experiencing chronic fibrositis (fibromyalgia) and Myofascial Pain Syndrome.
• People with joint pain from tendon micro-tears and inflammation.
• Individuals with chronic cluster and migraine headaches.

DOSAGE & DIRECTIONS

Take three capsules twice daily (spaced minimum of 3 hours apart) for ten days for maximum effectiveness; Thereafter, take two to three capsules daily for continued therapeutic benefit. Repeat procedure as necessary. Product most effective if taken on an empty stomach or immediately prior to a meal.

 

PROTOCOL FOR WEANING YOURSELF FROM NARCOTIC AND NSAID DRUGS.

Most prescription pain relievers are Schedule II narcotics containing the analgesic hydrocodone while leading OTC drugs contain acetaminophen, a leading cause of liver failure in the United States and Great Britain.

 

Considering the addictive and harmful nature of such drugs, Titan Laboratories has developed a specific protocol for weaning the patient off these side-effect laden drugs:

 

Month One. Take regular dosage of synthetic pain reliever. Also take 3 capsules twice daily (am & pm) of Factor Fourteen: Anodyne Plus. Be sure to space dosages two hours apart from the ingestion of synthetic drug.

 

Month Two. Reduce dosage of synthetic drug to every other day while maintaining the above dosage level of Factor Fourteen: Anodyne Plus.

 

Month Three. Discontinue synthetic drug while maintaining dosage level of Factor Fourteen: Anodyne Plus. 

 

 

CONTRAINDICATIONS & PRECAUTIONS 

 

Patients should not use sedative drugs in combination with Factor Fourteen. Never take supplements at the same time as prescription or OTC medications. This product not suitable for children under 8 years of age.

 

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Holistic Recommendations

Back pain, joint pain, muscle spasm, stress, anxiety, persistent headache, and migraine are all related to lifestyle, diet and how well the body is nourished. It is a sad fact of life that 90% of Americans show some signs of malnutrition!₂₉

An estimated 34 million Americans suffer from some form of chronic pain, defined as pain lasting for at least 3 months which is not relieved with conventional medicine.₃₀

Because pain is a subjective experience, patients are often faced with a medical establishment that does not trust their reports of pain and therefore, it is often inadequately treated. However, even if it cannot be measured and no physical explanation for it can be found, all pain is real.

Diet changes and supplementation with proven pain-relieving herbals and nutrients has been shown to ameliorate and relieve chronic pain, according to the consensus of doctors attending the 15th National Conference on Chronic Disease and Control, held in Washington in November 2000.

Common Back, Joint and Musculoskeletal Pain

Lumbar strain is the most common kind of low back pain and occurs when a muscle, tendon, or ligament is stretched beyond its normal limit.

Fibromyalgia is chronic muscle spasm associated with sleep disturbance and localized "tender points".

Myofascial Pain Syndrome is chronic muscle spasm associated with "trigger points" that cause a painful response when touched. Low back pain and neck pain is frequently associated with myofascial pain syndrome.

Coccyx pain, known as coccygodynia, results from a hard fall on the tail bone.

Degenerative Arthritis, Degenerative Disk, and Spinal Stenosis are all forms of wear-and-tear of the spine, known as osteoarthritis. "Arthritis" is a general term that means joint inflammation. In fact, inflammation causes most back pain and controlling the inflammation will, in most cases, lessen the pain significantly.

Common Causes of Back, Joint, and Muscle Pain

1. Being overweight. Excess poundage stresses the joints and exacerbates inflammation.

2. Poor posture. For example, people who hunch over their computers for many hours a day have higher than normal number of trigger points and muscle spasms.

3. A sedentary lifestyle. Being sedentary strongly encourages bone mineral loss.

4. Weak abdominal and back muscles due to a lack of exercise. Individuals should exercise at least three times a week for a minimum 30 minutes a day.

5. Continual heavy physical work requiring twisting and bending. Individuals must learn to relax and follow proper body movement procedures.

Migraine Pain

Migraines appear to occur as the result of functional disturbances of cranial circulation₃₁ and have been linked to food allergies, low thyroid function, and low immune system.

Recommendations for migraine relief:

1. Take Factor Fourteen: Anodyne Plus in recommended dosage.

2. Place the patient on a mega immunity supplement such as Factor One: Bio-Immunizer, especially if eating habits are poor.

3. Minimize or avoid alcohol, caffeine, dairy products, and chocolate, which have been determined to trigger migraine attacks.₃₂

4. Avoid exposure to cigarette smoke, hair sprays, perfumes and other pollutants which can precipitate migraine.₃₃

Conventional pain medicines  

fall into two major categories: non-steroidal anti-inflammatory drugs (NSAID's), which include aspirin, ibuprofen, and other salicylates, and Opiates (narcotics).

Unfortunately, for those with chronic back, joint, and muscle pain, NSAID's are associated with side effects including gastric distress, ulcers, internal bleeding, and dizziness. In fact, thousands of Americans die each year of NSAID-related hemorrhages. NOTE: Since 1988, the FDA's own advisory committee has been calling for new labeling for NSAID's but the FDA refuses to take action. NSAID's represent a $2 billion-plus market for drug companies.

Another side effect usually not mentioned with NSAID usage is their acceleration of cartilage destruction, and drying out of bone joints.₃₄ In short, while NSAID's appear fairly effective in suppressing the symptoms, they worsen the condition!

Botanical medicine (Phytoanalgesics)

Botanicals offer two major advantages over pharmaceutical drugs in combating chronic pain.

First, herbs and specific vitamins have a broader range of possible actions, especially when given in combination. These synergistic and complementary actions address several causes of pain simultaneously. This is especially important in chronic pain, because such pain is universally complicated by other problems, such as insomnia, anxiety, low immunity, fatigue, or allergies.

Second, herbs have less contraindications and side effects than pharmaceutical drugs. In fact, it is estimated 2 million Americans are hospitalized annually with drug side effects, and 100,000 die!₃₅

The multi-faceted Factor Fourteen: Anodyne Plus formulation functions as an analgesic to reduce pain; an anti-inflammatory to mitigate inflammation and allergic response; an anti-spasmodic to ease muscle tension; and a nevine to ameliorate anxiety and promote proper nerve function. This product has no known side effects when taken as instructed in the recommended dosage.

 

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FACTOR FOURTEEN FORMULATION
Two Capsules Equal:

Validation of Ingredients

VITAMIN B-1 (THIAMIN) enhances both blood formation and circulation, nervous tissue maintenance, and learning capacity.₁ This vitamin is not stored in the body and must be supplied daily, therefore, body tissues deplete rapidly when a deficiency occurs.₂ There are more American adults deficient in thiamin than in any other vitamin.₃

Thiamin has also been shown to protect against lead poisoning - highly significant in view of the widespread lead pollution in so many public water systems and manufactured products.₄ In adults, lead can cause nerve disorders, muscle and joint pain, mood changes, and sleep problems.₅

VITAMIN B-6 (PYRIDOXINE HCL) promotes the production of serotonin, melatonin, and dopamine which regulates sleep, pain, and mood.₆

Of all the B vitamins, B-6 is the most crucial for a healthy immune system.₇ Approximately 40% of all Americans are deficient in B-6, which is especially common for those who consume diets high in sugar and fat, and women on oral contraceptives.₈

VITAMIN B-12 (CYANOCOBALAMIN) alleviates neuro-psychiatric disorders and prevents mental deterioration. In a series of 39 patients treated for neurological symptoms related to B-12 deficiency, 100 percent showed improvements, sometimes dramatic improvement. The neuro-psychiatric symptoms included memory loss, disorientation, and impaired touch or pain perception.₉

DL-PHENYLALANINE (AMINO ACID) has been shown to have analgesic effects in both animals and humans and helps alleviate back pain. It is believed to work by inhibiting the breakdown of opiate-like substances called enkephalilns in the brain.₁₀ Basically, DL-Phenylalanine relieves chronic pain by altering pain response in the brain.

QUERCETIN (BIOFLAVONOID) is indicated in virtually all inflammatory and allergic conditions, as it appears to directly modulate the factors involved in inflammation and allergy.₁₁

Quercetin has been shown to inhibit many steps in eicosanoid metabolism. The result is a significant reduction in the formation of leukotrienes. Excessive leukotriene formation has been linked to asthma, back and leg pain.₁₂

Quercetin has been demonstrated, in vitro, to inhibit both viral replication and infectivity.₁₃ Quercetin and bromelain are synergistic and are taken in conjunction to enhance absorption.

GINGER ROOT (ZINGIBER OFFICINALE) produces anti-inflammatory activity similar to non-steroidal drugs. It interferes with the manufacture of prostaglandin and thus blocks inflammation.₁₄

A clinical study of 28 patients with rheumatoid arthritis, 18 with osteoarthritis, and 10 with muscular discomfort were given powdered ginger for periods ranging from 3 months to 2.5 years.₁₅ Seventy-five percent of the arthritis patients and 100 percent of the patients with muscular discomfort experienced relief in pain or swelling.

Because of its pharmacological activities on platelet function and inflammation, ginger has also been reported to be beneficial in migraine headache.₁₆

Ginger also ameliorates symptoms of nausea, motion and morning sickness, vertigo, dizziness and stomach disorders.₁₇

BROMELAIN (PINEAPPLE ENZYME) is an enzyme that acts as an anti-inflammatory agent in healing injuries, particularly sprains and strains, muscle injuries, and the pain, swelling, and tenderness that accompany sports injuries.₁₈

Double-blind research has shown that bromelain is effective for people suffering from sinusitis.₁₉ In addition, bromelain reduces the thickness of mucus, which may benefit patients with asthma and chronic bronchitis.₂₀

KAVA KAVA (PIPER METHYSTICUM) contains pain-relieving chemicals called lava-lactones which may have mild analgesic, anti-anxiety, muscle-relaxing, and anti-convulsant effects.₂₁

Anxiety intensifies pain and several European countries have approved kava preparations in the treatment of nervous anxiety on the basis of detailed pharmacological data and favorable clinical studies.₂₂

BUPLEURUM is a natural steroid similar to steroidal pain relieving drugs but without the destructive side effects.₂₃ Active constituents of Bupleurum have also been found to protect the liver, stomach and kidneys from toxic damage.

In a study of 40 patients with pathological fever, Bupleurum produced an antipyretic (fever alleviation) effect in 97.5% and achieved a reduction of 1 - 2 degrees C. in body temperature in 77.5%₂₄

FEVERFEW (TANACETUM PARTHENIUM) has been used for centuries to alleviate headaches and joint pain. Several double-blind studies involving patients with migraine have shown that feverfew reduces the severity, duration, and frequency of migraine headaches._25,26

WHITE WILLOW (SALIX SPP) is the natural compound from which aspirin was developed and has been used traditionally for fever, headache, pain, and rheumatic complaints.₂₇ In the body, salicin breaks down into salicylic acid, a compound possessing potent anti-inflammatory activity.₂₈ Unlike aspirin, white willow is safer and doesn't irritate the stomach.

 

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References

1. Lonsdale, D, et al., American J. of Clinical Nutrition, vol 33, pp. 205-11, 1980
2. Dunne, LJ, Nutrition Almanac, 3rd Ed., McGraw-Hill, NY, p. 21, 1990
3. Bicknell, F, et al., Vitamins in Medicine, Heinneman, London, 1945
4. Hendler, S, The Doctors' Vitamin and Mineral Encyclopedia, Simon & Schuster, NY, p. 27, 1991
5. Lead Fact Sheet, Environmental Health Center, Washington, DC, Nov. 3, 1998
6. Bender, D, Neurochemistry, vol 6, pp. 297-321, 1984
7. Hendler, S, Doctors' Vitamin and Mineral Encyclopedia, Simon & Schuster, NY, pp. 62-63, 1991
8. Howard, L, Nutritional Research, vol 48, pp. 169-77, 1990
9. Hendler, S, Doctors' Vitamin and Mineral Encyclopedia, Simon & Schuster, NY, p. 69, 1991
10. Bonica, J, et al., Advances in Pain Research and Therapy, vol 5, Raven Press, NY, NY, 1983
11. Bindoli, A, et al., "Inhibitory action of quercetin", Pharmacol Res Commun, Vol 17, pp. 831-9, 1985
12. Ford-Hutchinson, AW, J. Allergy Clin Immunol, vol 74, pp 437-40, 1984
13. Kaul, T, et al., J. Med Virol, vol 15, pp. 71-9, 1985
14. Weiner, M, Weiner's Herbal, Quantum Books, Mill Valley, CA 1992
15. Srivastava, KC, et al., Med Hypothesis, vol 39, pp. 342-48, 1992
16. Mustafa, T, et al., J. Ethnopharmacol, vol 29, pp. 267-73, 1990
17. Mowrey, DB, et al., The Lancet, pp. 655-57, Mar 20, 1982
18. Masson, M, Fortschr Med, vol 113, no. 19, pp. 303-6, 1995
19. Ryan, RE, Headache, vol 7, pp. 13-17, 1967
20. Schafer, A, et al., J. Clin Invest, vol 75, pp. 456-61, 1985
21. Buckley, JP, et al., Ethnopharmacoligical Search for Psychoactive Drugs, Raven Press, NY, pp. 141-51, 1979
22. Murray, M, The Healing Power of Herbs, 2nd Ed., Prima Publishing, Rocklin, CA, p. 215, 1995
23. Tang, W, et al., Chinese Drugs of Plant Origin, Springer-Verlag, Berlin, 1992
24. Chang, H, et al., Pharmacology and Applications of Chinese Materia Medica, World Scientic, Singapore, 1987
25. Johnson, ES, et al., British Med J., vol 291, pp. 569-73, 1985
26. Murphy, JJ, et al., The Lancet, vol ii, pp. 189-92, 1988
27. Weiss, RF, Herbal Medicine, Ab Arcanum, Gothernburg, Sweden, 1988
28. Germano, C, & Cabot, W, Nature's Pain Killers, Kensington Pub., NY, NY, p. 160, 1999

 

Validation of Holistic Recommendations

29. Lowenstein, FW, Bibliotheca Nutrito et Dieta, vol 30, 1981
30. Report of the American Chronic Pain Association, Rocklin, CA, 1996
31. Goadsby, PJ, Cephalgia, vol 17, no. 2, pp. 85-92, 1997
32. Duarte, A, Health Alternatives, Mega Systems, Morton Grove, IL, 1995
33. Meggs, WJ, Environmental Health Prespectives, vol 101, no. 3, pp. 234-38, 1993
34. Brooks, PM, et al., Journal Rheumatol, vol 9, pp. 3-5, 1982
35. Neergaard, L, News article, The Associated Press, Dec. 22, 2000

 

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