Based Natural Pain Control
Factor Fourteen: Anodyne Plus
A synergistic formulation of herbals and other nutrients
shown to have pain relieving properties against neurological
disorders, chronic back and joint pain, and migraine head
Botanicals offer a broader range of possible therapeutic
actions then pharmaceutical drugs in combating chronic
pain and have less side effects and contraindications.
Factor Fourteen: Anodyne Plus has no known side effects.
TO CONSIDER (OVERVIEW)
chronic back pain, lumbar strain, and coccyx pain.
experiencing persistent muscle spasm.
(Recommended in combination with Factor Six)
chronic fibrositis (fibromyalgia) and Myofascial Pain
joint pain from tendon micro-tears and inflammation.
with chronic cluster and migraine headaches.
DOSAGE & DIRECTIONS
Take two capsules twice daily
(spaced minimum of 3 hours apart) for maximum
effectiveness; Thereafter, take one to two capsules daily
for continued therapeutic benefit. Repeat procedure as necessary.
Product most effective if taken on an empty stomach or immediately
prior to a meal.
PROTOCOL FOR WEANING YOURSELF
FROM NARCOTIC AND NSAID DRUGS.
Most prescription pain relievers
are Schedule II narcotics containing the analgesic hydrocodone
while leading OTC drugs contain acetaminophen, a leading
cause of liver failure in the United States and Great Britain.
Considering the addictive and
harmful nature of such drugs, Titan Laboratories has developed
a specific protocol for weaning the patient off these side-effect
Month One. Take regular
dosage of synthetic pain reliever. Also take 3 capsules twice
daily (am & pm) of Factor Fourteen: Anodyne Plus.
Be sure to space dosages two hours apart from the ingestion
of synthetic drug.
Month Two. Reduce dosage
of synthetic drug to every other day while maintaining the
above dosage level of Factor Fourteen: Anodyne Plus.
Month Three. Discontinue
synthetic drug while maintaining dosage level of Factor
Fourteen: Anodyne Plus.
CONTRAINDICATIONS & PRECAUTIONS
Patients should not use sedative
drugs in combination with Factor Fourteen. Never take supplements
at the same time as prescription or OTC medications. This
product not suitable for children under 8 years of age.
pain, joint pain, muscle spasm, stress, anxiety, persistent
headache, and migraine are all related to lifestyle, diet
and how well the body is nourished. It is a sad fact of life
that 90% of Americans show some signs of malnutrition!29
An estimated 34 million Americans suffer from some form of
chronic pain, defined as pain lasting for at least 3 months
which is not relieved with conventional medicine.30
Because pain is a subjective experience, individuals are often
faced with a medical establishment that does not trust their
reports of pain and therefore, it is often inadequately treated.
However, even if it cannot be measured and no physical explanation
for it can be found, all pain is real.
Diet changes and supplementation with proven pain-relieving
herbals and nutrients has been shown to ameliorate and relieve
chronic pain, according to the consensus of doctors attending
the 15th National Conference on Chronic Disease and Control,
held in Washington in November 2000.
Common Back, Joint and Musculoskeletal
Lumbar strain is the most common kind of low back pain and
occurs when a muscle, tendon, or ligament is stretched beyond
its normal limit.
Fibromyalgia is chronic muscle spasm associated with sleep
disturbance and localized "tender points".
Myofascial Pain Syndrome is chronic muscle spasm associated
with "trigger points" that cause a painful response
when touched. Low back pain and neck pain is frequently associated
with myofascial pain syndrome.
Coccyx pain, known as coccygodynia, results from a hard fall
on the tail bone.
Degenerative Arthritis, Degenerative
Disk, and Spinal Stenosis are all forms of wear-and-tear of
the spine, known as osteoarthritis. "Arthritis"
is a general term that means joint inflammation. In fact,
inflammation causes most back pain and controlling the inflammation
will, in most cases, lessen the pain significantly.
Common Causes of Back, Joint, and Muscle
1. Being overweight. Excess poundage stresses the joints and
2. Poor posture. For example, people who hunch over their
computers for many hours a day have higher than normal number
of trigger points and muscle spasms.
3. A sedentary lifestyle. Being sedentary strongly encourages
bone mineral loss.
4. Weak abdominal and back muscles due to a lack of exercise.
Individuals should exercise at least three times a week for
a minimum 30 minutes a day.
5. Continual heavy physical work requiring twisting and bending.
Individuals must learn to relax and follow proper body movement
Migraines appear to occur as the result of functional disturbances
of cranial circulation31 and have been linked to
food allergies, low thyroid function, and low immune system.
Recommendations for migraine relief:
1. Take Factor Fourteen: Anodyne Plus in recommended dosage.
2. Minimize or avoid alcohol, caffeine, dairy products, and
chocolate, which have been determined to trigger migraine
3. Avoid exposure to cigarette smoke, hair sprays, perfumes
and other pollutants which can precipitate migraine.33
Conventional pain medicines
fall into two major categories:
non-steroidal anti-inflammatory drugs (NSAID's), which include
aspirin, ibuprofen, and other salicylates, and Opiates (narcotics).
Unfortunately, for those with chronic back, joint, and muscle
pain, NSAID's are associated with side effects including gastric
distress, ulcers, internal bleeding, and dizziness. In fact,
thousands of Americans die each year of NSAID-related hemorrhages.
NOTE: Since 1988, the FDA's own advisory committee has been
calling for new labeling for NSAID's but the FDA refuses to
take action. NSAID's represent a $2 billion-plus market for
Another side effect usually not mentioned with NSAID usage
is their acceleration of cartilage destruction, and drying
out of bone joints.34 In short, while NSAID's appear
fairly effective in suppressing the symptoms, they worsen
Botanical medicine (Phytoanalgesics)
Botanicals offer two major advantages over pharmaceutical
drugs in combating chronic pain.
First, herbs and specific vitamins have a broader range of
possible actions, especially when given in combination. These
synergistic and complementary actions address several causes
of pain simultaneously. This is especially important in chronic
pain, because such pain is universally complicated by other
problems, such as insomnia, anxiety, low immunity, fatigue,
Second, herbs have less contraindications and side effects
than pharmaceutical drugs. In fact, it is estimated 2 million
Americans are hospitalized annually with drug side effects,
and 100,000 die!35
The multi-faceted Factor Fourteen: Anodyne Plus formulation
functions as an analgesic
to reduce pain; an anti-inflammatory
to mitigate inflammation and allergic response; an anti-spasmodic
to ease muscle tension; and a nevine
to ameliorate anxiety and promote proper nerve
function. This product has no known side effects when taken
as instructed in the recommended dosage.
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FACTOR FOURTEEN FORMULATION
Two Capsules Equal:
B-6 (Pyridoxine HCL)
root (Zingiber officinale
Kava (stem & leaves)
B-1 (THIAMIN) enhances both blood formation and circulation,
nervous tissue maintenance, and learning capacity.1
This vitamin is not stored in the body and must be supplied
daily, therefore, body tissues deplete rapidly when a deficiency
occurs.2 There are more American adults deficient
in thiamin than in any other vitamin.3
Thiamin has also been shown to protect against lead poisoning
- highly significant in view of the widespread lead pollution
in so many public water systems and manufactured products.4
In adults, lead can cause nerve disorders, muscle and joint
pain, mood changes, and sleep problems.5
VITAMIN B-6 (PYRIDOXINE HCL) promotes the production
of serotonin, melatonin, and dopamine which regulates sleep,
pain, and mood.6
Of all the B vitamins, B-6 is the most crucial for a healthy
immune system.7 Approximately 40% of all Americans
are deficient in B-6, which is especially common for those
who consume diets high in sugar and fat, and women on oral
VITAMIN B-12 (CYANOCOBALAMIN) alleviates neuro-psychiatric
disorders and prevents mental deterioration. In a series of
39 patients treated for neurological symptoms related to B-12
deficiency, 100 percent showed improvements, sometimes dramatic
improvement. The neuro-psychiatric symptoms included memory
loss, disorientation, and impaired touch or pain perception.9
DL-PHENYLALANINE (AMINO ACID) has been shown to have
analgesic effects in both animals and humans and helps alleviate
back pain. It is believed to work by inhibiting the breakdown
of opiate-like substances called enkephalilns in the brain.10
Basically, DL-Phenylalanine relieves chronic pain by altering
pain response in the brain.
QUERCETIN (BIOFLAVONOID) is indicated in virtually
all inflammatory and allergic conditions, as it appears to
directly modulate the factors involved in inflammation and
Quercetin has been shown to inhibit many steps in eicosanoid
metabolism. The result is a significant reduction in the formation
of leukotrienes. Excessive leukotriene formation has been
linked to asthma, back and leg pain.12
Quercetin has been demonstrated, in vitro, to inhibit both
viral replication and infectivity.13 Quercetin
and bromelain are synergistic and are taken in conjunction
to enhance absorption.
GINGER ROOT (ZINGIBER OFFICINALE) produces anti-inflammatory
activity similar to non-steroidal drugs. It interferes with
the manufacture of prostaglandin and thus blocks inflammation.14
A clinical study of 28 patients with rheumatoid arthritis,
18 with osteoarthritis, and 10 with muscular discomfort were
given powdered ginger for periods ranging from 3 months to
2.5 years.15 Seventy-five percent of the arthritis
patients and 100 percent of the patients with muscular discomfort
experienced relief in pain or swelling.
Because of its pharmacological activities on platelet function
and inflammation, ginger has also been reported to be beneficial
in migraine headache.16
Ginger also ameliorates symptoms of nausea, motion and morning
sickness, vertigo, dizziness and stomach disorders.17
BROMELAIN (PINEAPPLE ENZYME) is an enzyme that acts
as an anti-inflammatory agent in healing injuries, particularly
sprains and strains, muscle injuries, and the pain, swelling,
and tenderness that accompany sports injuries.18
Double-blind research has shown that bromelain is effective
for people suffering from sinusitis.19 In addition,
bromelain reduces the thickness of mucus, which may benefit
patients with asthma and chronic bronchitis.20
KAVA KAVA (PIPER METHYSTICUM) contains pain-relieving
chemicals called lava-lactones which may have mild analgesic,
anti-anxiety, muscle-relaxing, and anti-convulsant effects.21
Anxiety intensifies pain and several European countries have
approved kava preparations in the treatment of nervous anxiety
on the basis of detailed pharmacological data and favorable
BUPLEURUM is a natural steroid similar to steroidal
pain relieving drugs but without the destructive side effects.23
Active constituents of Bupleurum have also been found to protect
the liver, stomach and kidneys from toxic damage.
In a study of 40 patients with pathological fever, Bupleurum
produced an antipyretic (fever alleviation) effect in 97.5%
and achieved a reduction of 1 - 2 degrees C. in body temperature
FEVERFEW (TANACETUM PARTHENIUM) has been used for centuries
to alleviate headaches and joint pain. Several double-blind
studies involving patients with migraine have shown that feverfew
reduces the severity, duration, and frequency of migraine
WHITE WILLOW (SALIX SPP) is the natural compound from
which aspirin was developed and has been used traditionally
for fever, headache, pain, and rheumatic complaints.27
In the body, salicin breaks down into salicylic acid, a compound
possessing potent anti-inflammatory activity.28
Unlike aspirin, white willow is safer and doesn't irritate
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Lonsdale, D, et al., American J. of Clinical Nutrition, vol
33, pp. 205-11, 1980
2. Dunne, LJ, Nutrition Almanac, 3rd Ed., McGraw-Hill, NY,
p. 21, 1990
3. Bicknell, F, et al., Vitamins in Medicine, Heinneman, London,
4. Hendler, S, The Doctors' Vitamin and Mineral Encyclopedia,
Simon & Schuster, NY, p. 27, 1991
5. Lead Fact Sheet, Environmental Health Center, Washington,
DC, Nov. 3, 1998
6. Bender, D, Neurochemistry, vol 6, pp. 297-321, 1984
7. Hendler, S, Doctors' Vitamin and Mineral Encyclopedia,
Simon & Schuster, NY, pp. 62-63, 1991
8. Howard, L, Nutritional Research, vol 48, pp. 169-77, 1990
9. Hendler, S, Doctors' Vitamin and Mineral Encyclopedia,
Simon & Schuster, NY, p. 69, 1991
10. Bonica, J, et al., Advances in Pain Research and Therapy,
vol 5, Raven Press, NY, NY, 1983
11. Bindoli, A, et al., "Inhibitory action of quercetin",
Pharmacol Res Commun, Vol 17, pp. 831-9, 1985
12. Ford-Hutchinson, AW, J. Allergy Clin Immunol, vol 74,
pp 437-40, 1984
13. Kaul, T, et al., J. Med Virol, vol 15, pp. 71-9, 1985
14. Weiner, M, Weiner's Herbal, Quantum Books, Mill Valley,
15. Srivastava, KC, et al., Med Hypothesis, vol 39, pp. 342-48,
16. Mustafa, T, et al., J. Ethnopharmacol, vol 29, pp. 267-73,
17. Mowrey, DB, et al., The Lancet, pp. 655-57, Mar 20, 1982
18. Masson, M, Fortschr Med, vol 113, no. 19, pp. 303-6, 1995
19. Ryan, RE, Headache, vol 7, pp. 13-17, 1967
20. Schafer, A, et al., J. Clin Invest, vol 75, pp. 456-61,
21. Buckley, JP, et al., Ethnopharmacoligical Search for Psychoactive
Drugs, Raven Press, NY, pp. 141-51, 1979
22. Murray, M, The Healing Power of Herbs, 2nd Ed., Prima
Publishing, Rocklin, CA, p. 215, 1995
23. Tang, W, et al., Chinese Drugs of Plant Origin, Springer-Verlag,
24. Chang, H, et al., Pharmacology and Applications of Chinese
Materia Medica, World Scientic, Singapore, 1987
25. Johnson, ES, et al., British Med J., vol 291, pp. 569-73,
26. Murphy, JJ, et al., The Lancet, vol ii, pp. 189-92, 1988
27. Weiss, RF, Herbal Medicine, Ab Arcanum, Gothernburg, Sweden,
28. Germano, C, & Cabot, W, Nature's Pain Killers, Kensington
Pub., NY, NY, p. 160, 1999
of Holistic Recommendations
29. Lowenstein, FW, Bibliotheca Nutrito et Dieta, vol 30,
30. Report of the American Chronic Pain Association, Rocklin,
31. Goadsby, PJ, Cephalgia, vol 17, no. 2, pp. 85-92, 1997
32. Duarte, A, Health Alternatives, Mega Systems, Morton Grove,
33. Meggs, WJ, Environmental Health Prespectives, vol 101,
no. 3, pp. 234-38, 1993
34. Brooks, PM, et al., Journal Rheumatol, vol 9, pp. 3-5,
35. Neergaard, L, News article, The Associated Press, Dec.
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